In a new paper, Miguel Lanaspa and I show that muscle wasting (sarcopenia) in chronic kidney disease may be mediated by insulin resistance. Insulin resistance results in a reduction in glucose and phosphate from entering the cell, and over time …
Podcast – The External Medicine Podcast – Exploring the Outskirts of Medicine
Synopsis: A discussion of a biological switch that triggers the development of obesity. The role of fructose in the activation of the switch. Listen to the podcast here.
Video – Part one of my three part Master Series on Nature Wants Us to Be Fat
This is part I of the my three part Master Series on Nature Wants Us to Be Fat. Part I is on the existence of a biological switch to become fat, that it can be triggered by intake of added …
A Brief Pictorial View of How Fructose Activates the Survival Switch
Fructose is distinct from all other carbohydrates in that it triggers a reduction in energy (ATP) in the cell, which is called the energy depletion pathway. The fall in energy (or ATP) causes a survival switch to be turned on, …
Podcast – with Ben Azadi and The Keto Kamp Podcast
This is a discussion of my new book, Nature Wants Us to Be Fat. It describes how there is a specific biologic switch that animals use to become fat. It is usually triggered by fructose, either from our diet or …
The Great Controversies – Challenging the Insulin Hypothesis
One of the more important hypotheses on what causes obesity is the insulin hypothesis. According to this hypothesis, obesity is not driven so much by the amount of calories we eat, but rather by whether the food we eat stimulates …