In a new paper, Miguel Lanaspa and I show that muscle wasting (sarcopenia) in chronic kidney disease may be mediated by insulin resistance. Insulin resistance results in a reduction in glucose and phosphate from entering the cell, and over time this can lead to less energy production by the muscle cell. This is associated with both a reduction in muscle mass and some local inflammation. Preventing insulin resistance by reducing carbohydrates (especially HFCS and sugar) and salt could be beneficial.
Read the article here.