Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?
Alzheimer’s disease is a devastating condition that is the sixth most common cause of death. To date the cause remains unknown. Here is the paper I wrote with David Perlmutter and Dale Bredesen detailing the evidence that excessive intake of sugar, high glycemic carbs, and salty foods may be playing a role. The underlying mechanism—fructose production in the brain, which is also discussed in detail in Nature Wants Us to Be Fat.
Read the article here.
